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Treatments - Azzalure

azzalure derma fillers logoPatient Information

Azzalure uses the toxin produced by the bacteria.  The amount of toxin used is minimal and generally well tolerated in clinical trials.  The toxin temporarily weakens the muscles responsible for developing facial expression lines caused by muscle activity.  Static facial lines, e.g. those due to sun damage, will not usually respond to treatment with Botulinum Toxin, as they are not caused by muscle activity.

Azzalure is licensed for the temporary improvement of moderate to severe vertical lines between the eyebrows (glabellar lines) and is injected into the skin to reduce these lines.  You are having these injections because the severity of your lines has had an important psychological impact on you.

Treatment is not recommended if you are pregnant or breastfeeding.

After treatment with Azzalure® you should start to see an improvement within 2 to 3 days, however the full effect can take up to 30 days.  The benefits of treatment usually last between 3 and 4 months, but can vary depending on your individual response.

The most common side effects of Azzalure® are headache and injection reactions e.g. redness, swelling, irritation, rash, itching, numbness, pain, discomfort, stinging, bruising and bleeding.  Normally these reactions are mild to moderate, reversible and occur in the first week after treatment.  There is also a small possibility of slight dropping of the eyelid or visual problems.

Very rarely, Botulinum Toxin may result in muscle weakness away from the site of injection.

If any symptoms last for more than one week or you are concerned about any symptoms you should report them to your practitioner as soon as possible.  Seek urgent medical help if you have difficulties breathing, swallowing, speaking or if your face swells up (allergic reactions are very rare).

Azzalure® may cause temporary blurred vision or muscle weakness.  If affected, you should not drive or use machinery.

Azzalure® contains a very small amount of albumin which comes from human blood.  It is very unlikely that this could pass on an infection, but it cannot be entirely ruled out.

What is Botulinum Toxin?

Botulinum Toxin is a bacterium that blocks the release of acetylcholine, the substance responsible for transmitting electrical impulses that elicit muscle contraction.  In medicine, Botulinum Toxin is injected directly into hyperactive muscles.  It has been safely and effectively used for treatment of strabismus (cross-eye) and blepharospasm (lid spasm) since the early eighties.

How Does Botulinum Toxin Work?

Hyperactivity of the facial expression muscles often results in the development of deep frown lines, forehead lines and/or crow’s feet.  Injecting Botulinum Toxin into the affected area temporarily paralyses the underlying muscles responsible for wrinkling, giving the face a more relaxed and pleasant appearance.  The wrinkles become smoother or disappear altogether.

When and How Long Does Botulinum Toxin Work?

  • The initial effects of treatment become visible within 48 to 72 hours.  The maximum effect is reached in approximately 3 weeks.
  • Your facial expression will become more relaxed but by no means mask-like.  The overall result is very natural.
  • The effect of treatment generally lasts for 3 to 4 months.  Re-treatment is then required.

Potential Adverse Effects (side effects)

Botulinum Toxin injection is generally a safe and effective treatment method.  Nevertheless, certain side effects can occur but, like the intended treatment effects, they are mostly reversible.

At this appointment, you will be informed about the potential side effects of Botulinum Toxin therapy, contra-indications to therapy, and potential drug interactions.

Potential Side Effects:

  • Bruising or swelling at the injection site
  • Headache
  • Tiredness, pain in the arms and legs
  • Temporary drooping of the eyebrow or upper eyelid
  • Brief visual disturbances
  • Dryness of the eyes
  • Skin rash
  • Itching
  • Allergic reaction (very rare)
  • Dry mouth
  • Muscle atrophy

Contra-indications (Please ensure you inform the Doctor if you have any of the following):

  • Pregnancy
  • Breast-feeding
  • Myasthenia Gravis
  • Lambert-Eaton syndrome
  • Blood coagulation disorders

Drug Interactions

Drug interactions can occur when Botulinum Toxin is used concomitantly with other medications.  Since these medications can alter the effects of Botulinum Toxin, you must ensure that your doctor is aware of any current medications you are taking, especially:

  • Aminoglycoside antibiotics
  • Anaesthetics
  • Muscle relaxants


Pricing Information

The initial consultation is free. Treatment prices start from £195.

If you would like to arrange an appointment or require any further information please contact us on 01903 503311.

Examples of Azzalure

Frown lines on forehead
Azzalure treatment example
Azzalure treatment example
Creases between eyes
Azzalure treatment example
Azzalure treatment example

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